Drug interactions
Everolimus + Sipuleucel-t
Severity: Moderate
Everolimus and Sipuleucel-t: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sipuleucel-T depends on the patient's own immune cells mounting an antitumor response. Immunosuppressants such as everolimus may weaken that response and reduce the benefit of treatment.
What this interaction means in plain words
Everolimus and Sipuleucel-t can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: mTOR inhibition impairs T-cell activation and proliferation needed for sipuleucel-T efficacy.
What to do
Avoid immunosuppressants around leukapheresis and infusion where possible. If everolimus is essential, weigh the likely reduced benefit of sipuleucel-T.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Sipuleucel-t?
MediHelp rates the interaction as moderate. Everolimus and Sipuleucel-t can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sipuleucel-T depends on the patient's own immune cells mounting an antitumor response. Immunosuppressants such as everolimus may weaken that response and reduce the benefit of treatment.
How serious is the interaction between Everolimus and Sipuleucel-t?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid immunosuppressants around leukapheresis and infusion where possible. If everolimus is essential, weigh the likely reduced benefit of sipuleucel-T.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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