Drug interactions
Everolimus + Sofosbuvir / velpatasvir
Severity: Moderate
Everolimus and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits P-glycoprotein and may increase everolimus concentrations. Everolimus has a narrow therapeutic range, so toxicity may result.
What this interaction means in plain words
Everolimus and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Velpatasvir inhibits P-glycoprotein and possibly CYP3A4, reducing everolimus clearance and increasing absorption.
What to do
Monitor everolimus trough concentrations and clinical toxicity during treatment, and reduce the dose if levels are elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Everolimus and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits P-glycoprotein and may increase everolimus concentrations. Everolimus has a narrow therapeutic range, so toxicity may result.
How serious is the interaction between Everolimus and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations and clinical toxicity during treatment, and reduce the dose if levels are elevated.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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