Drug interactions
Everolimus + Tofacitinib
Severity: Major
Everolimus and Tofacitinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus is an mTOR inhibitor with immunosuppressive effects, and tofacitinib is a JAK inhibitor. Together they substantially increase the risk of serious infections and possibly malignancy.
What this interaction means in plain words
Everolimus and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Everolimus belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic immunosuppression through different pathways.
What to do
Avoid combining; tofacitinib labeling cautions against use with potent immunosuppressants. If unavoidable, monitor for infection and review the need for both agents regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Tofacitinib?
MediHelp rates the interaction as major. Everolimus and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Everolimus is an mTOR inhibitor with immunosuppressive effects, and tofacitinib is a JAK inhibitor. Together they substantially increase the risk of serious infections and possibly malignancy.
How serious is the interaction between Everolimus and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; tofacitinib labeling cautions against use with potent immunosuppressants. If unavoidable, monitor for infection and review the need for both agents regularly.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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