Drug interactions
Everolimus + Topiramate
Severity: Moderate
Everolimus and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate may slightly lower everolimus concentrations through weak CYP3A4 induction, which could reduce immunosuppressive or antitumor effect. The effect is expected to be modest.
What this interaction means in plain words
Everolimus and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Everolimus belongs to Oncology; Topiramate belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 (and possibly P-gp) by topiramate increasing everolimus clearance.
What to do
Monitor everolimus trough concentrations and clinical response when starting or stopping topiramate, and adjust the everolimus dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topiramate
Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Topiramate?
MediHelp rates the interaction as moderate. Everolimus and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topiramate may slightly lower everolimus concentrations through weak CYP3A4 induction, which could reduce immunosuppressive or antitumor effect. The effect is expected to be modest.
How serious is the interaction between Everolimus and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor everolimus trough concentrations and clinical response when starting or stopping topiramate, and adjust the everolimus dose as needed.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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