Drug interactions
Everolimus + Typhoid polysaccharide vaccine
Severity: Minor
Everolimus and Typhoid polysaccharide vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The typhoid polysaccharide vaccine is non-live and does not cause infection. Everolimus may lessen the antibody response, leaving reduced protection.
What this interaction means in plain words
Everolimus and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Immunosuppression by mTOR inhibition may reduce vaccine immunogenicity.
What to do
Use the inactivated vaccine rather than the live one and vaccinate before everolimus when possible. Advise continued food and water precautions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as minor. Everolimus and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The typhoid polysaccharide vaccine is non-live and does not cause infection. Everolimus may lessen the antibody response, leaving reduced protection.
How serious is the interaction between Everolimus and Typhoid polysaccharide vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the inactivated vaccine rather than the live one and vaccinate before everolimus when possible. Advise continued food and water precautions.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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