Drug interactions
Everolimus + Varicella virus vaccine live
Severity: Contraindicated
Everolimus and Varicella virus vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live varicella vaccine may cause disseminated varicella in immunosuppressed patients receiving everolimus. The vaccine response may also be impaired.
What this interaction means in plain words
Everolimus and Varicella virus vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
mTOR-mediated immunosuppression permits replication of live attenuated virus and reduces vaccine immunity.
What to do
Avoid live varicella vaccine during everolimus therapy and immunize beforehand where feasible. Follow current guidance on the interval after stopping treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Varicella virus vaccine live?
MediHelp rates the interaction as contraindicated. Everolimus and Varicella virus vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live varicella vaccine may cause disseminated varicella in immunosuppressed patients receiving everolimus. The vaccine response may also be impaired.
How serious is the interaction between Everolimus and Varicella virus vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live varicella vaccine during everolimus therapy and immunize beforehand where feasible. Follow current guidance on the interval after stopping treatment.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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