Drug interactions
Everolimus + Zoster vaccine recombinant
Severity: Moderate
Everolimus and Zoster vaccine recombinant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Everolimus is immunosuppressive and may blunt the immune response to the recombinant zoster vaccine, which is non-live and safe to give. Protection against shingles may be reduced.
What this interaction means in plain words
Everolimus and Zoster vaccine recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition suppresses T-cell proliferation and the vaccine-induced immune response.
What to do
Give the vaccine ideally before starting everolimus or when immunosuppression is lowest. Do not delay vaccination if this is not possible, and do not rely on a single dose for protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Everolimus with Zoster vaccine recombinant?
MediHelp rates the interaction as moderate. Everolimus and Zoster vaccine recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Everolimus is immunosuppressive and may blunt the immune response to the recombinant zoster vaccine, which is non-live and safe to give. Protection against shingles may be reduced.
How serious is the interaction between Everolimus and Zoster vaccine recombinant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine ideally before starting everolimus or when immunosuppression is lowest. Do not delay vaccination if this is not possible, and do not rely on a single dose for protection.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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