Drug interactions
Exemestane + Idelalisib
Severity: Moderate
Exemestane and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and exemestane is metabolized by CYP3A4. Exposure to exemestane may increase, although its wide safety margin makes serious toxicity less likely.
What this interaction means in plain words
Exemestane and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Exemestane belongs to Oncology; Idelalisib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition by idelalisib reduces exemestane clearance.
What to do
No routine dose adjustment is needed, but monitor for exemestane adverse effects. Reassess if symptoms such as bone pain or fatigue worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Exemestane
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Exemestane with Idelalisib?
MediHelp rates the interaction as moderate. Exemestane and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and exemestane is metabolized by CYP3A4. Exposure to exemestane may increase, although its wide safety margin makes serious toxicity less likely.
How serious is the interaction between Exemestane and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed, but monitor for exemestane adverse effects. Reassess if symptoms such as bone pain or fatigue worsen.
What other medicines interact with Exemestane?
MediHelp also lists interactions of Exemestane with, for example, Bazedoxifene-conjugated estrogens, Desogestrel-ethinyl estradiol, Estradiol. The full list is on the Exemestane page.
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