Drug interactions
Exemestane + Levoketoconazole
Severity: Moderate
Exemestane and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and may increase exposure to exemestane. Exemestane has a wide therapeutic margin, so the effect is usually tolerable, but adverse effects may be more pronounced.
What this interaction means in plain words
Exemestane and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Exemestane belongs to Oncology; Levoketoconazole belongs to Endocrine.
Why it happens
Levoketoconazole inhibits CYP3A4-mediated oxidative metabolism of exemestane.
What to do
No empirical dose adjustment is required; monitor for exemestane adverse effects and consider an alternative if tolerability becomes a problem.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Exemestane
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Exemestane with Levoketoconazole?
MediHelp rates the interaction as moderate. Exemestane and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and may increase exposure to exemestane. Exemestane has a wide therapeutic margin, so the effect is usually tolerable, but adverse effects may be more pronounced.
How serious is the interaction between Exemestane and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is required; monitor for exemestane adverse effects and consider an alternative if tolerability becomes a problem.
What other medicines interact with Exemestane?
MediHelp also lists interactions of Exemestane with, for example, Bazedoxifene-conjugated estrogens, Desogestrel-ethinyl estradiol, Estradiol. The full list is on the Exemestane page.
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