Drug interactions
Exemestane + Nevirapine
Severity: Moderate
Exemestane and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exemestane is cleared mainly by CYP3A4, and nevirapine can reduce its levels, possibly weakening estrogen suppression in breast cancer treatment.
What this interaction means in plain words
Exemestane and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Exemestane belongs to Oncology; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, increasing exemestane metabolism.
What to do
Consider increasing exemestane to 50 mg daily after a meal as the labeling advises for strong CYP3A4 inducers, and monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Exemestane
Frequently asked questions
Can I take Exemestane with Nevirapine?
MediHelp rates the interaction as moderate. Exemestane and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Exemestane is cleared mainly by CYP3A4, and nevirapine can reduce its levels, possibly weakening estrogen suppression in breast cancer treatment.
How serious is the interaction between Exemestane and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider increasing exemestane to 50 mg daily after a meal as the labeling advises for strong CYP3A4 inducers, and monitor clinical response.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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