Drug interactions
Ezogabine + Haloperidol
Severity: Moderate
Ezogabine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol prolongs the QT interval and ezogabine has been associated with QT prolongation, so concurrent use may add to the risk of ventricular arrhythmias including torsades de pointes. The risk is higher with electrolyte disturbance, cardiac disease or higher doses.
What this interaction means in plain words
Ezogabine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization causing QT prolongation.
What to do
Obtain a baseline ECG and monitor the QTc during therapy, and correct potassium and magnesium abnormalities. Consider an alternative if the QTc becomes significantly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Haloperidol?
MediHelp rates the interaction as moderate. Ezogabine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol prolongs the QT interval and ezogabine has been associated with QT prolongation, so concurrent use may add to the risk of ventricular arrhythmias including torsades de pointes. The risk is higher with electrolyte disturbance, cardiac disease or higher doses.
How serious is the interaction between Ezogabine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc during therapy, and correct potassium and magnesium abnormalities. Consider an alternative if the QTc becomes significantly prolonged.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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