Drug interactions
Ezogabine + Mefloquine
Severity: Moderate
Ezogabine and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine can cause QT prolongation and mefloquine has similar effects, so combined use may increase arrhythmia risk. Both drugs also have CNS effects such as confusion and psychiatric symptoms that could be additive.
What this interaction means in plain words
Ezogabine and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation through effects on cardiac repolarization, plus overlapping neuropsychiatric toxicity.
What to do
Monitor the ECG and electrolytes, and watch for neuropsychiatric symptoms. Choose another antimalarial where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Mefloquine?
MediHelp rates the interaction as moderate. Ezogabine and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine can cause QT prolongation and mefloquine has similar effects, so combined use may increase arrhythmia risk. Both drugs also have CNS effects such as confusion and psychiatric symptoms that could be additive.
How serious is the interaction between Ezogabine and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and electrolytes, and watch for neuropsychiatric symptoms. Choose another antimalarial where possible.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
Full monographs, dosing and an interaction checker in the MediHelp app
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