Drug interactions
Ezogabine + Moxifloxacin
Severity: Moderate
Ezogabine and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT prolongation, and moxifloxacin also lengthens the QT interval. Used together they may increase the risk of ventricular arrhythmia, particularly in patients with cardiac disease or electrolyte disturbance.
What this interaction means in plain words
Ezogabine and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive effects on cardiac repolarization leading to QT prolongation.
What to do
Monitor ECG and correct potassium and magnesium during co-administration. Consider an alternative antibiotic in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Moxifloxacin?
MediHelp rates the interaction as moderate. Ezogabine and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine has been associated with QT prolongation, and moxifloxacin also lengthens the QT interval. Used together they may increase the risk of ventricular arrhythmia, particularly in patients with cardiac disease or electrolyte disturbance.
How serious is the interaction between Ezogabine and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium during co-administration. Consider an alternative antibiotic in patients with other QT risk factors.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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