Drug interactions
Ezogabine + Osimertinib
Severity: Moderate
Ezogabine and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib causes dose-related QTc prolongation, and ezogabine has a modest QT effect. The combination may increase the risk of torsades de pointes, especially in patients with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Ezogabine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Osimertinib belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Perform periodic ECG monitoring and check electrolytes during co-administration. Correct abnormalities and reassess the combination if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezogabine
Other interactions of Osimertinib
Frequently asked questions
Can I take Ezogabine with Osimertinib?
MediHelp rates the interaction as moderate. Ezogabine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib causes dose-related QTc prolongation, and ezogabine has a modest QT effect. The combination may increase the risk of torsades de pointes, especially in patients with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Ezogabine and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG monitoring and check electrolytes during co-administration. Correct abnormalities and reassess the combination if the QTc becomes markedly prolonged.
What other medicines interact with Ezogabine?
MediHelp also lists interactions of Ezogabine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ezogabine page.
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