Drug interactions
Ezogabine + Voriconazole
Severity: Moderate
Ezogabine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ezogabine and voriconazole can prolong the QT interval, so combining them may have an additive effect on cardiac repolarization. This increases the risk of torsades de pointes, especially in patients with other risk factors.
What this interaction means in plain words
Ezogabine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezogabine belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Check a baseline ECG and electrolytes and monitor the QTc during combined therapy. Correct hypokalemia and hypomagnesemia, and avoid the combination in congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Ezogabine with Voriconazole?
MediHelp rates the interaction as moderate. Ezogabine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ezogabine and voriconazole can prolong the QT interval, so combining them may have an additive effect on cardiac repolarization. This increases the risk of torsades de pointes, especially in patients with other risk factors.
How serious is the interaction between Ezogabine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and monitor the QTc during combined therapy. Correct hypokalemia and hypomagnesemia, and avoid the combination in congenital long QT syndrome.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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