Drug interactions
Famotidine + Linagliptin-metformin
Severity: Minor
Famotidine and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine may slightly raise metformin exposure, but any effect is small and rarely clinically relevant. It is much weaker than that seen with cimetidine.
What this interaction means in plain words
Famotidine and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Famotidine belongs to Gastrointestinal Tract; Linagliptin-metformin belongs to Endocrine.
Why it happens
Possible competition for renal tubular secretion via organic cation transporters.
What to do
No dose change is usually needed; monitor glucose and renal function in patients with reduced kidney function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Famotidine
Frequently asked questions
Can I take Famotidine with Linagliptin-metformin?
MediHelp rates the interaction as minor. Famotidine and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine may slightly raise metformin exposure, but any effect is small and rarely clinically relevant. It is much weaker than that seen with cimetidine.
How serious is the interaction between Famotidine and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor glucose and renal function in patients with reduced kidney function.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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