Drug interactions
Famotidine + Mifepristone
Severity: Moderate
Famotidine and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT interval prolongation, though famotidine's effect is mainly seen in renal impairment. Combined use may add to arrhythmia risk, particularly with high-dose mifepristone as used in Cushing syndrome.
What this interaction means in plain words
Famotidine and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Famotidine belongs to Gastrointestinal Tract; Mifepristone belongs to Endocrine.
Why it happens
Additive effects on cardiac repolarization (QTc prolongation).
What to do
Obtain a baseline ECG and correct potassium and magnesium if using long-term mifepristone. Reduce famotidine dose in renal impairment and monitor QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famotidine
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Famotidine with Mifepristone?
MediHelp rates the interaction as moderate. Famotidine and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT interval prolongation, though famotidine's effect is mainly seen in renal impairment. Combined use may add to arrhythmia risk, particularly with high-dose mifepristone as used in Cushing syndrome.
How serious is the interaction between Famotidine and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium if using long-term mifepristone. Reduce famotidine dose in renal impairment and monitor QTc.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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