Drug interactions
Famotidine + Pexidartinib
Severity: Moderate
Famotidine and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid-reducing agents lower the solubility of pexidartinib, so coadministration with famotidine is expected to reduce its absorption and exposure. Reduced exposure may diminish effectiveness in tenosynovial giant cell tumor.
What this interaction means in plain words
Famotidine and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Famotidine belongs to Gastrointestinal Tract; Pexidartinib belongs to Oncology.
Why it happens
Increased gastric pH decreases the pH-dependent solubility and absorption of pexidartinib.
What to do
Avoid proton pump inhibitors; if an H2 antagonist is needed, give pexidartinib at least 2 hours before or 10 hours after it. Monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Famotidine and Pexidartinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Famotidine
Other interactions of Pexidartinib
Frequently asked questions
Can I take Famotidine with Pexidartinib?
MediHelp rates the interaction as moderate. Famotidine and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Acid-reducing agents lower the solubility of pexidartinib, so coadministration with famotidine is expected to reduce its absorption and exposure. Reduced exposure may diminish effectiveness in tenosynovial giant cell tumor.
How serious is the interaction between Famotidine and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid proton pump inhibitors; if an H2 antagonist is needed, give pexidartinib at least 2 hours before or 10 hours after it. Monitor clinical response.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
