Drug interactions
Famotidine + Saxagliptin-metformin
Severity: Minor
Famotidine and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine may modestly raise metformin concentrations by competing for renal tubular secretion. Clinical significance is usually small, especially at normal renal function.
What this interaction means in plain words
Famotidine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Famotidine belongs to Gastrointestinal Tract; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Competition for renal tubular cationic transporters (OCT2/MATE) reduces metformin clearance.
What to do
No dose change is usually needed; monitor glucose and renal function, particularly in patients with reduced eGFR.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Famotidine and Saxagliptin-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Saxagliptin-metformin
Other interactions of Famotidine
Frequently asked questions
Can I take Famotidine with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Famotidine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine may modestly raise metformin concentrations by competing for renal tubular secretion. Clinical significance is usually small, especially at normal renal function.
How serious is the interaction between Famotidine and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor glucose and renal function, particularly in patients with reduced eGFR.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
