Drug interactions
Famotidine + Sparsentan
Severity: Moderate
Famotidine and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is less soluble at higher pH, so acid-reducing agents may lower its exposure. Reduced exposure could weaken its effect on proteinuria in IgA nephropathy.
What this interaction means in plain words
Famotidine and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Famotidine belongs to Gastrointestinal Tract; Sparsentan belongs to Genitourinary.
Why it happens
Elevated gastric pH reduces the solubility and absorption of sparsentan.
What to do
Monitor proteinuria and clinical response; consider separating doses or choosing a non-acid-suppressing alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famotidine
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Famotidine with Sparsentan?
MediHelp rates the interaction as moderate. Famotidine and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan is less soluble at higher pH, so acid-reducing agents may lower its exposure. Reduced exposure could weaken its effect on proteinuria in IgA nephropathy.
How serious is the interaction between Famotidine and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor proteinuria and clinical response; consider separating doses or choosing a non-acid-suppressing alternative.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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