Drug interactions
Famotidine + Tafenoquine
Severity: Moderate
Famotidine and Tafenoquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafenoquine inhibits renal OCT2 and MATE transporters in vitro, and famotidine is cleared in part through renal tubular secretion. Famotidine levels could rise, increasing dose-related adverse effects, particularly in renal impairment.
What this interaction means in plain words
Famotidine and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Famotidine belongs to Gastrointestinal Tract; Tafenoquine belongs to Anti Parasitic.
Why it happens
Inhibition of renal OCT2/MATE transporters by tafenoquine may reduce tubular secretion of famotidine.
What to do
Monitor for famotidine adverse effects such as CNS effects; reduce the famotidine dose in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famotidine
Other interactions of Tafenoquine
- Dofetilide + Tafenoquine Major
- Alogliptin-metformin + Tafenoquine Moderate
- Amantadine + Tafenoquine Moderate
- Amiloride + Tafenoquine Moderate
- Canagliflozin-metformin + Tafenoquine Moderate
- Cimetidine + Tafenoquine Moderate
Frequently asked questions
Can I take Famotidine with Tafenoquine?
MediHelp rates the interaction as moderate. Famotidine and Tafenoquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafenoquine inhibits renal OCT2 and MATE transporters in vitro, and famotidine is cleared in part through renal tubular secretion. Famotidine levels could rise, increasing dose-related adverse effects, particularly in renal impairment.
How serious is the interaction between Famotidine and Tafenoquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for famotidine adverse effects such as CNS effects; reduce the famotidine dose in patients with renal impairment.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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