Drug interactions
Famotidine + Tolbutamide
Severity: Minor
Famotidine and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine may modestly increase sulfonylurea exposure, potentially strengthening glucose lowering. Clinically significant hypoglycemia is uncommon but possible.
What this interaction means in plain words
Famotidine and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Famotidine belongs to Gastrointestinal Tract; Tolbutamide belongs to Endocrine.
Why it happens
Altered gastric pH may increase sulfonylurea absorption; the mechanism is not firmly established.
What to do
No empirical dose change is needed. Advise patients to monitor blood glucose when starting or stopping famotidine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Famotidine
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Famotidine with Tolbutamide?
MediHelp rates the interaction as minor. Famotidine and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine may modestly increase sulfonylurea exposure, potentially strengthening glucose lowering. Clinically significant hypoglycemia is uncommon but possible.
How serious is the interaction between Famotidine and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Advise patients to monitor blood glucose when starting or stopping famotidine.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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