Drug interactions
Famotidine + Trilaciclib
Severity: Moderate
Famotidine and Trilaciclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits OCT2 and MATE transporters involved in renal secretion of famotidine. Famotidine concentrations may therefore increase rather than decrease, raising the risk of dose-related adverse effects.
What this interaction means in plain words
Famotidine and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Famotidine belongs to Gastrointestinal Tract; Trilaciclib belongs to Oncology.
Why it happens
Trilaciclib inhibits renal OCT2, MATE1 and MATE2-K, reducing tubular secretion of famotidine.
What to do
Monitor for famotidine-related adverse effects, especially CNS effects, and consider dose reduction in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Famotidine
Other interactions of Trilaciclib
Frequently asked questions
Can I take Famotidine with Trilaciclib?
MediHelp rates the interaction as moderate. Famotidine and Trilaciclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilaciclib inhibits OCT2 and MATE transporters involved in renal secretion of famotidine. Famotidine concentrations may therefore increase rather than decrease, raising the risk of dose-related adverse effects.
How serious is the interaction between Famotidine and Trilaciclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for famotidine-related adverse effects, especially CNS effects, and consider dose reduction in renal impairment.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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