Drug interactions
Famotidine + Vitamin B12
Severity: Minor
Famotidine and Vitamin B12: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic famotidine use reduces gastric acid, which can lessen release of B12 from food proteins. Clinically significant deficiency is uncommon but possible with prolonged use and other risk factors.
What this interaction means in plain words
Famotidine and Vitamin B12 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Famotidine belongs to Gastrointestinal Tract; Vitamin B12 belongs to Gastrointestinal Tract.
Why it happens
Reduced gastric acid impairs liberation of protein-bound B12.
What to do
Monitor B12 in long-term users who are older or have poor intake. Supplement if levels are low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Famotidine and Vitamin B12, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vitamin B12
- Chloramphenicol + Vitamin B12 Moderate
- Dichlorphenamide + Vitamin B12 Moderate
- Metformin + Vitamin B12 Moderate
- Neomycin po + Vitamin B12 Moderate
- Aspirin / citric acid / sodium bicarbonate + Vitamin B12 Minor
- Aspirin + Vitamin B12 Minor
Other interactions of Famotidine
Frequently asked questions
Can I take Famotidine with Vitamin B12?
MediHelp rates the interaction as minor. Famotidine and Vitamin B12 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic famotidine use reduces gastric acid, which can lessen release of B12 from food proteins. Clinically significant deficiency is uncommon but possible with prolonged use and other risk factors.
How serious is the interaction between Famotidine and Vitamin B12?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor B12 in long-term users who are older or have poor intake. Supplement if levels are low.
What other medicines interact with Vitamin B12?
MediHelp also lists interactions of Vitamin B12 with, for example, Chloramphenicol, Dichlorphenamide, Metformin. The full list is on the Vitamin B12 page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
