Drug interactions
Fedratinib + Fluticasone furoate
Severity: Moderate
Fedratinib and Fluticasone furoate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may modestly increase fluticasone furoate exposure. Systemic corticosteroid effects are possible with prolonged use.
What this interaction means in plain words
Fedratinib and Fluticasone furoate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fedratinib inhibits CYP3A4, reducing fluticasone metabolism.
What to do
Monitor for signs of corticosteroid excess during long-term use and consider reducing the fluticasone dose or changing agent if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fedratinib and Fluticasone furoate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Fluticasone furoate?
MediHelp rates the interaction as moderate. Fedratinib and Fluticasone furoate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may modestly increase fluticasone furoate exposure. Systemic corticosteroid effects are possible with prolonged use.
How serious is the interaction between Fedratinib and Fluticasone furoate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess during long-term use and consider reducing the fluticasone dose or changing agent if they occur.
What other medicines interact with Fedratinib?
MediHelp also lists interactions of Fedratinib with, for example, Thioridazine, Amobarbital, Apalutamide. The full list is on the Fedratinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
