Drug interactions
Fedratinib + Lansoprazole
Severity: Minor
Fedratinib and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolised by CYP3A4 and CYP2C19, and combined inhibition of these enzymes could raise its exposure. Lansoprazole is only a weak inhibitor of these enzymes, so the effect is likely small and has not been formally studied.
What this interaction means in plain words
Fedratinib and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Possible weak inhibition of CYP3A4 and CYP2C19 by lansoprazole reducing fedratinib clearance, not well established.
What to do
No empirical dose change is needed; monitor for fedratinib toxicity such as nausea, anemia and neurological symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Lansoprazole?
MediHelp rates the interaction as minor. Fedratinib and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib is metabolised by CYP3A4 and CYP2C19, and combined inhibition of these enzymes could raise its exposure. Lansoprazole is only a weak inhibitor of these enzymes, so the effect is likely small and has not been formally studied.
How serious is the interaction between Fedratinib and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for fedratinib toxicity such as nausea, anemia and neurological symptoms.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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