Drug interactions
Fedratinib + Metformin
Severity: Moderate
Fedratinib and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits renal transporters that clear metformin, which can raise metformin exposure. Higher levels increase the risk of gastrointestinal effects and, rarely, lactic acidosis, especially in renal impairment.
What this interaction means in plain words
Fedratinib and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Metformin belongs to Endocrine.
Why it happens
Fedratinib inhibits OCT2 and MATE1/2-K, decreasing renal tubular secretion of metformin.
What to do
Monitor glycemic control and renal function, and watch for signs of metformin toxicity. Reduce the metformin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Other interactions of Metformin
Frequently asked questions
Can I take Fedratinib with Metformin?
MediHelp rates the interaction as moderate. Fedratinib and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits renal transporters that clear metformin, which can raise metformin exposure. Higher levels increase the risk of gastrointestinal effects and, rarely, lactic acidosis, especially in renal impairment.
How serious is the interaction between Fedratinib and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and renal function, and watch for signs of metformin toxicity. Reduce the metformin dose if needed.
What other medicines interact with Fedratinib?
MediHelp also lists interactions of Fedratinib with, for example, Thioridazine, Amobarbital, Apalutamide. The full list is on the Fedratinib page.
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