Drug interactions
Fedratinib + Pimozide
Severity: Major
Fedratinib and Pimozide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4, CYP2D6 and CYP2C19, so it may raise pimozide levels. Pimozide is a QT-prolonging drug, so increased exposure raises the risk of arrhythmia.
What this interaction means in plain words
Fedratinib and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fedratinib belongs to Oncology; Pimozide belongs to Central Nervous System.
Why it happens
Fedratinib inhibits CYP3A4 and CYP2D6, reducing pimozide clearance.
What to do
Avoid the combination if possible. If it is needed, monitor ECG and consider reducing the pimozide dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Pimozide?
MediHelp rates the interaction as major. Fedratinib and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fedratinib inhibits CYP3A4, CYP2D6 and CYP2C19, so it may raise pimozide levels. Pimozide is a QT-prolonging drug, so increased exposure raises the risk of arrhythmia.
How serious is the interaction between Fedratinib and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is needed, monitor ECG and consider reducing the pimozide dose.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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