Drug interactions
Fedratinib + Propranolol
Severity: Moderate
Fedratinib and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP2D6 and can raise concentrations of propranolol, which is partly metabolized by this enzyme. This may lead to bradycardia and hypotension.
What this interaction means in plain words
Fedratinib and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Propranolol belongs to Cardiovascular.
Why it happens
Fedratinib inhibits CYP2D6, reducing propranolol clearance.
What to do
Monitor heart rate and blood pressure and reduce the propranolol dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Propranolol?
MediHelp rates the interaction as moderate. Fedratinib and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP2D6 and can raise concentrations of propranolol, which is partly metabolized by this enzyme. This may lead to bradycardia and hypotension.
How serious is the interaction between Fedratinib and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and reduce the propranolol dose if bradycardia or hypotension occurs.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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