Drug interactions
Fedratinib + Venlafaxine
Severity: Moderate
Fedratinib and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4 and CYP2D6, both of which metabolise venlafaxine. This can increase venlafaxine exposure and the risk of dose-related adverse effects, including hypertension and serotonergic toxicity.
What this interaction means in plain words
Fedratinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 and CYP3A4 by fedratinib reduces venlafaxine clearance.
What to do
Monitor blood pressure and tolerability, and reduce the venlafaxine dose if adverse effects appear. Reassess if fedratinib dosing changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Venlafaxine?
MediHelp rates the interaction as moderate. Fedratinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib inhibits CYP3A4 and CYP2D6, both of which metabolise venlafaxine. This can increase venlafaxine exposure and the risk of dose-related adverse effects, including hypertension and serotonergic toxicity.
How serious is the interaction between Fedratinib and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability, and reduce the venlafaxine dose if adverse effects appear. Reassess if fedratinib dosing changes.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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