Drug interactions
Fedratinib + Zolpidem
Severity: Moderate
Fedratinib and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may increase zolpidem exposure, causing more pronounced or prolonged sedation. The effect is expected to be modest but relevant in older patients.
What this interaction means in plain words
Fedratinib and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fedratinib belongs to Oncology; Zolpidem belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated zolpidem metabolism by fedratinib.
What to do
Start with a reduced zolpidem dose and monitor for daytime sedation and psychomotor impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Zolpidem?
MediHelp rates the interaction as moderate. Fedratinib and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may increase zolpidem exposure, causing more pronounced or prolonged sedation. The effect is expected to be modest but relevant in older patients.
How serious is the interaction between Fedratinib and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a reduced zolpidem dose and monitor for daytime sedation and psychomotor impairment.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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