Drug interactions
Felodipine + Lemborexant
Severity: Moderate
Felodipine and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine is a weak CYP3A4 inhibitor and can raise lemborexant exposure. Higher levels may increase next-day somnolence, impaired alertness and other CNS effects.
What this interaction means in plain words
Felodipine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Lemborexant belongs to Central Nervous System.
Why it happens
Felodipine weakly inhibits CYP3A4, the main enzyme metabolizing lemborexant, reducing its clearance.
What to do
Follow lemborexant labeling and use the lower maximum nightly dose recommended with weak CYP3A4 inhibitors. Monitor for daytime drowsiness and impaired psychomotor performance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Felodipine with Lemborexant?
MediHelp rates the interaction as moderate. Felodipine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felodipine is a weak CYP3A4 inhibitor and can raise lemborexant exposure. Higher levels may increase next-day somnolence, impaired alertness and other CNS effects.
How serious is the interaction between Felodipine and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow lemborexant labeling and use the lower maximum nightly dose recommended with weak CYP3A4 inhibitors. Monitor for daytime drowsiness and impaired psychomotor performance.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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