Drug interactions
Felodipine + Mifepristone
Severity: Moderate
Felodipine and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise felodipine concentrations. This can cause hypotension, flushing, headache and peripheral edema.
What this interaction means in plain words
Felodipine and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4, reducing felodipine metabolism.
What to do
Monitor blood pressure and edema, and reduce the felodipine dose if hypotension or adverse effects occur. Consider an alternative antihypertensive for prolonged mifepristone therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Felodipine with Mifepristone?
MediHelp rates the interaction as moderate. Felodipine and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may raise felodipine concentrations. This can cause hypotension, flushing, headache and peripheral edema.
How serious is the interaction between Felodipine and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema, and reduce the felodipine dose if hypotension or adverse effects occur. Consider an alternative antihypertensive for prolonged mifepristone therapy.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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