Drug interactions
Felodipine + Nicardipine
Severity: Moderate
Felodipine and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are dihydropyridine calcium channel blockers, so combining them gives duplicate therapy with additive hypotension, edema and reflex tachycardia. Nicardipine also inhibits CYP3A4 and may raise felodipine levels.
What this interaction means in plain words
Felodipine and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Additive calcium channel blockade plus CYP3A4 inhibition by nicardipine.
What to do
Avoid using both agents together; choose a single dihydropyridine or a drug from another class.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Felodipine with Nicardipine?
MediHelp rates the interaction as moderate. Felodipine and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are dihydropyridine calcium channel blockers, so combining them gives duplicate therapy with additive hypotension, edema and reflex tachycardia. Nicardipine also inhibits CYP3A4 and may raise felodipine levels.
How serious is the interaction between Felodipine and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both agents together; choose a single dihydropyridine or a drug from another class.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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