Drug interactions
Felodipine + Pancuronium
Severity: Minor
Felodipine and Pancuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can modestly potentiate non-depolarizing neuromuscular blockers such as pancuronium, which may prolong or deepen neuromuscular blockade. The effect is usually small but may delay recovery after surgery.
What this interaction means in plain words
Felodipine and Pancuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Pancuronium belongs to Musculoskeletal.
Why it happens
Calcium channel blockade reduces presynaptic acetylcholine release and may add to the postsynaptic block produced by pancuronium.
What to do
Monitor neuromuscular function with train-of-four during anesthesia and titrate pancuronium to effect. Ensure full recovery before extubation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pancuronium
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Pancuronium?
MediHelp rates the interaction as minor. Felodipine and Pancuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers can modestly potentiate non-depolarizing neuromuscular blockers such as pancuronium, which may prolong or deepen neuromuscular blockade. The effect is usually small but may delay recovery after surgery.
How serious is the interaction between Felodipine and Pancuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four during anesthesia and titrate pancuronium to effect. Ensure full recovery before extubation.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
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