Drug interactions
Felodipine + Phentolamine
Severity: Moderate
Felodipine and Phentolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure through vasodilation, so combined use can cause excessive hypotension and reflex tachycardia. Dizziness, syncope and orthostatic symptoms are more likely, particularly when starting treatment or raising doses.
What this interaction means in plain words
Felodipine and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Phentolamine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic vasodilation from calcium channel blockade and alpha-adrenergic antagonism.
What to do
Monitor blood pressure and heart rate, including standing readings, when combining or adjusting either drug. Reduce the dose of one agent if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Felodipine with Phentolamine?
MediHelp rates the interaction as moderate. Felodipine and Phentolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure through vasodilation, so combined use can cause excessive hypotension and reflex tachycardia. Dizziness, syncope and orthostatic symptoms are more likely, particularly when starting treatment or raising doses.
How serious is the interaction between Felodipine and Phentolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, including standing readings, when combining or adjusting either drug. Reduce the dose of one agent if symptomatic hypotension develops.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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