Drug interactions
Felodipine + Prednisone
Severity: Minor
Felodipine and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids may modestly induce CYP3A4 and reduce felodipine exposure, potentially weakening blood pressure control. Corticosteroids can also raise blood pressure and cause fluid retention, opposing antihypertensive therapy.
What this interaction means in plain words
Felodipine and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Prednisone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 induction by prednisone lowers felodipine levels, plus pharmacodynamic opposition through sodium and fluid retention.
What to do
Monitor blood pressure and edema during prolonged prednisone therapy and adjust the felodipine dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Prednisone?
MediHelp rates the interaction as minor. Felodipine and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids may modestly induce CYP3A4 and reduce felodipine exposure, potentially weakening blood pressure control. Corticosteroids can also raise blood pressure and cause fluid retention, opposing antihypertensive therapy.
How serious is the interaction between Felodipine and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema during prolonged prednisone therapy and adjust the felodipine dose if control is lost.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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