Drug interactions
Felodipine + Secobarbital
Severity: Moderate
Felodipine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and can reduce felodipine concentrations, potentially causing loss of blood pressure or angina control. The effect develops over days to weeks of barbiturate exposure.
What this interaction means in plain words
Felodipine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Secobarbital induces hepatic and intestinal CYP3A4, increasing felodipine metabolism.
What to do
Monitor blood pressure and heart rate, and increase felodipine dose if needed. Reassess dose when the barbiturate is stopped to avoid excessive effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Felodipine with Secobarbital?
MediHelp rates the interaction as moderate. Felodipine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and can reduce felodipine concentrations, potentially causing loss of blood pressure or angina control. The effect develops over days to weeks of barbiturate exposure.
How serious is the interaction between Felodipine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and increase felodipine dose if needed. Reassess dose when the barbiturate is stopped to avoid excessive effect.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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