Drug interactions
Felodipine + Topotecan
Severity: Moderate
Felodipine and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine is a weak P-glycoprotein inhibitor and may raise topotecan exposure, particularly oral topotecan, whose absorption depends on efflux transporters. The clinical significance is uncertain for felodipine specifically, but higher topotecan levels could worsen myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Felodipine and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Topotecan belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein and possibly BCRP-mediated efflux increases topotecan absorption and reduces its clearance.
What to do
Monitor blood counts closely if felodipine is used with topotecan, especially the oral formulation. Consider an alternative antihypertensive if neutropenia or thrombocytopenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Frequently asked questions
Can I take Felodipine with Topotecan?
MediHelp rates the interaction as moderate. Felodipine and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felodipine is a weak P-glycoprotein inhibitor and may raise topotecan exposure, particularly oral topotecan, whose absorption depends on efflux transporters. The clinical significance is uncertain for felodipine specifically, but higher topotecan levels could worsen myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Felodipine and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely if felodipine is used with topotecan, especially the oral formulation. Consider an alternative antihypertensive if neutropenia or thrombocytopenia develops.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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