Drug interactions
Felodipine + Venetoclax
Severity: Moderate
Felodipine and Venetoclax: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine may weakly inhibit P-glycoprotein and could increase venetoclax exposure. The clinical effect is uncertain but may increase venetoclax toxicities such as neutropenia.
What this interaction means in plain words
Felodipine and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Venetoclax belongs to Miscellaneous.
Why it happens
Possible inhibition of P-gp efflux of venetoclax by felodipine, increasing its absorption and exposure.
What to do
Monitor blood counts and signs of venetoclax toxicity, and follow labeling for dose reduction with P-gp inhibitors if a clinically relevant effect emerges. Consider an alternative antihypertensive if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Felodipine and Venetoclax, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Felodipine with Venetoclax?
MediHelp rates the interaction as moderate. Felodipine and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felodipine may weakly inhibit P-glycoprotein and could increase venetoclax exposure. The clinical effect is uncertain but may increase venetoclax toxicities such as neutropenia.
How serious is the interaction between Felodipine and Venetoclax?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of venetoclax toxicity, and follow labeling for dose reduction with P-gp inhibitors if a clinically relevant effect emerges. Consider an alternative antihypertensive if toxicity occurs.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
