Drug interactions
Felodipine + Verapamil
Severity: Moderate
Felodipine and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and can increase felodipine exposure, and both are calcium channel blockers with additive hypotensive effects. This may cause marked hypotension, edema and reflex tachycardia, and combining two calcium channel blockers rarely offers added benefit.
What this interaction means in plain words
Felodipine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4 metabolism of felodipine, with additive calcium channel blockade.
What to do
Avoid routine combination; if used, start felodipine at a low dose and monitor blood pressure, heart rate and edema. Reduce the dose if hypotension or adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Felodipine with Verapamil?
MediHelp rates the interaction as moderate. Felodipine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits CYP3A4 and can increase felodipine exposure, and both are calcium channel blockers with additive hypotensive effects. This may cause marked hypotension, edema and reflex tachycardia, and combining two calcium channel blockers rarely offers added benefit.
How serious is the interaction between Felodipine and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination; if used, start felodipine at a low dose and monitor blood pressure, heart rate and edema. Reduce the dose if hypotension or adverse effects occur.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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