Drug interactions
Felodipine + Zafirlukast
Severity: Minor
Felodipine and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine is a highly CYP3A4-dependent substrate with extensive first-pass metabolism, so inhibitors can increase peripheral edema, flushing and hypotension. Zafirlukast is a weak inhibitor so the effect is likely modest.
What this interaction means in plain words
Felodipine and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Zafirlukast belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zafirlukast may reduce felodipine first-pass metabolism.
What to do
Monitor blood pressure and for edema or flushing. Reduce the felodipine dose if hypotension or marked edema develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Zafirlukast?
MediHelp rates the interaction as minor. Felodipine and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felodipine is a highly CYP3A4-dependent substrate with extensive first-pass metabolism, so inhibitors can increase peripheral edema, flushing and hypotension. Zafirlukast is a weak inhibitor so the effect is likely modest.
How serious is the interaction between Felodipine and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema or flushing. Reduce the felodipine dose if hypotension or marked edema develops.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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