Drug interactions
Fenbufen + Hydrochlorothiazide-irbesartan
Severity: Moderate
Fenbufen and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenbufen can reduce the antihypertensive effect of irbesartan and, in combination with a thiazide diuretic and ARB, increase the risk of acute kidney injury and hyperkalemia, especially in older or dehydrated patients.
What this interaction means in plain words
Fenbufen and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis reduces renal blood flow and glomerular filtration, compounding ARB and diuretic hemodynamic effects.
What to do
Avoid prolonged NSAID use where possible; if needed, monitor blood pressure, creatinine and potassium and maintain hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Fenbufen with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Fenbufen and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenbufen can reduce the antihypertensive effect of irbesartan and, in combination with a thiazide diuretic and ARB, increase the risk of acute kidney injury and hyperkalemia, especially in older or dehydrated patients.
How serious is the interaction between Fenbufen and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged NSAID use where possible; if needed, monitor blood pressure, creatinine and potassium and maintain hydration.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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