Drug interactions
Fenbufen + Hydrochlorothiazide
Severity: Moderate
Fenbufen and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenbufen can blunt the diuretic and antihypertensive effect of thiazides and may impair renal function. Competition for tubular secretion may also change exposure to either drug.
What this interaction means in plain words
Fenbufen and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention, plus possible competition for renal anion transport.
What to do
Monitor blood pressure, edema, and renal function, particularly in older or volume-depleted patients, and use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fenbufen and Hydrochlorothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Fenbufen with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Fenbufen and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenbufen can blunt the diuretic and antihypertensive effect of thiazides and may impair renal function. Competition for tubular secretion may also change exposure to either drug.
How serious is the interaction between Fenbufen and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema, and renal function, particularly in older or volume-depleted patients, and use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
