Drug interactions
Fenbufen + Sotalol
Severity: Moderate
Fenbufen and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenbufen can blunt the antihypertensive effect of beta-blockers through prostaglandin inhibition and fluid retention. They can also impair renal function, which may raise sotalol levels since it is renally cleared.
What this interaction means in plain words
Fenbufen and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin inhibition causes sodium retention and reduced renal perfusion, opposing the antihypertensive effect and reducing sotalol clearance.
What to do
Monitor blood pressure, renal function and QTc with prolonged NSAID use, and use the lowest effective NSAID dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Fenbufen with Sotalol?
MediHelp rates the interaction as moderate. Fenbufen and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as fenbufen can blunt the antihypertensive effect of beta-blockers through prostaglandin inhibition and fluid retention. They can also impair renal function, which may raise sotalol levels since it is renally cleared.
How serious is the interaction between Fenbufen and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and QTc with prolonged NSAID use, and use the lowest effective NSAID dose.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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