Drug interactions
Fenfluramine + Insulin lispro
Severity: Moderate
Fenfluramine and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine has been reported to improve peripheral glucose uptake and lower blood glucose. With insulin lispro this may increase the risk of hypoglycemia.
What this interaction means in plain words
Fenfluramine and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Insulin lispro belongs to Endocrine.
Why it happens
Fenfluramine increases peripheral glucose uptake, adding to the glucose-lowering effect of insulin.
What to do
Monitor blood glucose when fenfluramine is started or stopped and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Insulin lispro?
MediHelp rates the interaction as moderate. Fenfluramine and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine has been reported to improve peripheral glucose uptake and lower blood glucose. With insulin lispro this may increase the risk of hypoglycemia.
How serious is the interaction between Fenfluramine and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fenfluramine is started or stopped and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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