Drug interactions
Fenfluramine + Ketamine
Severity: Moderate
Fenfluramine and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine is a serotonergic anticonvulsant that can cause somnolence, and ketamine may add to sedation. The combination has no well-characterized specific interaction, but additive CNS effects are plausible.
What this interaction means in plain words
Fenfluramine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Ketamine belongs to Central Nervous System.
Why it happens
Probable additive CNS depression; no specific mechanism established.
What to do
Monitor sedation and blood pressure when ketamine is given to patients on fenfluramine, and adjust ketamine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Ketamine?
MediHelp rates the interaction as moderate. Fenfluramine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine is a serotonergic anticonvulsant that can cause somnolence, and ketamine may add to sedation. The combination has no well-characterized specific interaction, but additive CNS effects are plausible.
How serious is the interaction between Fenfluramine and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure when ketamine is given to patients on fenfluramine, and adjust ketamine dose accordingly.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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