Drug interactions
Fenfluramine + Pirbuterol
Severity: Moderate
Fenfluramine and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine is a serotonergic anorectic agent that can raise blood pressure and heart rate in some patients. Combined with a beta-agonist this may add to cardiovascular stimulation.
What this interaction means in plain words
Fenfluramine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic cardiovascular effects through different pathways.
What to do
Monitor heart rate and blood pressure when starting or adjusting either drug, and reduce the dose if tachycardia or hypertension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Pirbuterol?
MediHelp rates the interaction as moderate. Fenfluramine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine is a serotonergic anorectic agent that can raise blood pressure and heart rate in some patients. Combined with a beta-agonist this may add to cardiovascular stimulation.
How serious is the interaction between Fenfluramine and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or adjusting either drug, and reduce the dose if tachycardia or hypertension occurs.
What other medicines interact with Fenfluramine?
MediHelp also lists interactions of Fenfluramine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Fenfluramine page.
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