Drug interactions
Fenfluramine + Salbutamol
Severity: Moderate
Fenfluramine and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise heart rate and blood pressure through sympathomimetic activity. Fenfluramine also carries a risk of valvular heart disease and pulmonary hypertension, so added adrenergic load may be undesirable in affected patients.
What this interaction means in plain words
Fenfluramine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenfluramine belongs to Central Nervous System; Salbutamol belongs to Respiratory.
Why it happens
Additive pharmacodynamic sympathomimetic cardiovascular effects (beta-agonism with serotonergic and noradrenergic release).
What to do
Monitor heart rate and blood pressure when salbutamol is used regularly or at high doses with fenfluramine. Follow the echocardiographic monitoring required for fenfluramine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Salbutamol?
MediHelp rates the interaction as moderate. Fenfluramine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise heart rate and blood pressure through sympathomimetic activity. Fenfluramine also carries a risk of valvular heart disease and pulmonary hypertension, so added adrenergic load may be undesirable in affected patients.
How serious is the interaction between Fenfluramine and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when salbutamol is used regularly or at high doses with fenfluramine. Follow the echocardiographic monitoring required for fenfluramine.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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