Drug interactions
Fenoprofen + Metolazone
Severity: Moderate
Fenoprofen and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen may blunt the diuretic and antihypertensive effects of metolazone, and the pair can contribute to renal impairment in volume-depleted or elderly patients.
What this interaction means in plain words
Fenoprofen and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Metolazone belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduced renal perfusion.
What to do
Monitor blood pressure, weight, edema and renal function. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Metolazone
Frequently asked questions
Can I take Fenoprofen with Metolazone?
MediHelp rates the interaction as moderate. Fenoprofen and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen may blunt the diuretic and antihypertensive effects of metolazone, and the pair can contribute to renal impairment in volume-depleted or elderly patients.
How serious is the interaction between Fenoprofen and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight, edema and renal function. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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